I have found another culprit in the slow save (and launch vs2005).
Much like the HKEY_CURRENT_USER\Software\Microsoft\VisualStudio\8.0\ProjectMRUList
there may be offending remote projects in:
HKEY_CURRENT_USER\Software\Microsoft\VisualStudio\8.0\DefaultFileOpenLocation
HKEY_CURRENT_USER\Software\Microsoft\VisualStudio\8.0\DefaultOpenProjectLocation
and any other values in HKEY_CURRENT_USER\Software\Microsoft\VisualStudio\8.0
This is, of course if you have opened a remote project that no longer exists.
My problem came from the fact that i was setting up a new server and migrating projects. After some setup time, but before we added it to our network permanently it was shut down. During this time my VS2005 slowed to a near halt. Apparently, the last opened location gets det to the default and since, for me, that was a server that was off line, VS2005 (on any action) was extremely slow (apparently looking like crazy for the absent server).
Why VS2005 does this i have no idea.