I am not aware of your exact requirement, you may try the following(although the method is not very 'clean'):
In the handler for the OnTreeNodeDataBound, try wrapping the node text in a span as:
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e.Node.Text = "<span onclick='javascript:myNodeClickHandler()'>"+e.Node.Text+"</span>";
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That would probably work but tooltips may show that big ugly text.
Hope that helps.
cheers!!
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